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KMID : 0861020100250030097
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Korea Journal of Herbology
2010 Volume.25 No. 3 p.97 ~ p.101
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Anti-nociceptive and anti-inflammatory effects of Geranii Herba
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Ju Mi-Sun
Jeong Hyun-Uk
Kim Hyo-Geun
Park Gun-Hyuk
Youn You-Suk
Kim Young-Ock
Kim Sun-Yeou
Oh Myung-Sook
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Abstract
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Objectives : The present study investigated the anti-nociceptive and anti-inflammatory properties of the water extract of Geranii Herba (The stem and leaves of Geranium thunbergii Sieb. et Zucc.) in the animal models of pain and inflammation.
Methods : We evaluated the anti-nociceptive and anti-inflammatory activities of Geranii Herba extract (GHE) using the writhing test, tail-flick test, carrageenan-induced paw edema and xylene-induced ear edema models. Two dose of GHE (100 and 1000 mg/kg) was administrated orally to the mice. Control group received normal saline and ibuprofen (50 mg/kg) was used as a positive control drug.
Results: GHE 1000 mg/kg treated group showed an increased tail-flick response time in the tail-flick test and inhibitory effect on writhing syndrome induced by acetic acid. Treatment with GHE at the same dose inhibited ear edema induced by xylene and foot edema induced by carrageenan toxicity.
Conclusion: The results demonstrate that GHE has anti-nociceptive and anti-inflammatory effects in the various models of nociception and inflammation.
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KEYWORD
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Geranii Herba, anti-nociceptive, anti-inflammatory, tail-flick, carrageenan, writhing syndrome, xylene
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